TRAM-34

TRAM-34 is a highly selective blocker of intermediate-conductance calcium-activated K+ channel (IKCa1) (Kd=20 nM) .

Product Specifications

CAS Number

[289905-88-0]

UNSPSC

12352005

Hazard Statement

H302, H413

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/TRAM-34.html

Concentration

10mM

Purity

99.78

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

ClC1=CC=CC=C1C(N2N=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4

Molecular Formula

C22H17ClN2

Molecular Weight

344.84

Precautions

H302, H413

References & Citations

[1]Wulff H, et al. Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant. Proc Natl Acad Sci U S A. 2000 Jul 5;97 (14) :8151-6.|[2]Roy JW, et al. The intermediate conductance Ca2+-activated K+ channel inhibitor TRAM-34 stimulates proliferation of breast cancer cells via activation of oestrogen receptors. Br J Pharmacol. 2010 Feb 1;159 (3) :650-8.|[3]Chen YJ, et al. The KCa3.1 blocker TRAM-34 reduces infarction and neurological deficit in a rat model of ischemia/reperfusion stroke. J Cereb Blood Flow Metab. 2011 Dec;31 (12) :2363-74.