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NE-100 (hydrochloride)

NE-100 hydrochloride is an orally active and selective sigma-1 receptor antagonist with an IC50 of 4.16 nM. NE-100 hydrochloride can improve cognitive impairment and has neuroprotective and antipsychotic activities. NE-100 hydrochloride can be used for research on nervous system diseases[1][2][3].

Product Specifications

CAS Number

149409-57-4

UNSPSC

12352005

Target

ATF6; Sigma Receptor

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ne-100-hydrochloride.html

Purity

99.1

Solubility

H2O : ≥ 100 mg/mL

Smiles

CCCN(CCC)CCC1=CC=C(OC)C(OCCC2=CC=CC=C2)=C1.[H]Cl

Molecular Formula

C23H34ClNO2

Molecular Weight

391.97

References & Citations

[1]Ono Y, et al. A sigma-1 receptor antagonist (NE-100) prevents tunicamycin-induced cell death via GRP78 induction in hippocampal cells. Biochem Biophys Res Commun. 2013 May 17;434 (4) :904-9.|[2]Okuyama S, et al. NE-100, a novel sigma receptor ligand: in vivo tests. Life Sci. 1993;53 (18) :PL285-90.|[3]Okuyama S, et al. Effect of NE-100, a novel sigma receptor ligand, on phencyclidine- induced delayed cognitive dysfunction in rats. Neurosci Lett. 1995 Apr 7;189 (1) :60-2.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Sigma 1 Receptor

Available Sizes

Frequently Asked Questions

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