Human Neuregulin-1/NRG1-Beta1 ELISA Kit

Detect Range: 62.5 pg/mL-4000 pg/mL. Sensitivity: 10 pg/mL. Gene_name: NRG1. Gene_full_name: Pro-neuregulin-1 membrane-bound isoform. Protein_name: Pro-neuregulin-1 membrane-bound isoform. Sample Type: cell culture supernates cell lysates tissue homogenates serum and plasma (heparin EDTA) . Tmb_incubation: 25-30 min. Capture_antibody: monoclonal antibody from mouse. Detection_antibody: polyclonal antibody from goat. Research_category: neuroscience|neurology process|growth and development|neurotrophins|neurogenesis. Sequence_similarities: Belongs to the neuregulin family. Tissue_specificity: Type I isoforms are the predominant formsexpressed in the endocardium. Isoform alpha is expressed inbreast ovary testis prostate heart skeletal muscle lung placenta liver kidney salivary gland small intestine and brain but not in uterus stomach pancreas and spleen. Isoform 3 is thepredominant form in mesenchymal cells and in non-neuronal organs whereas isoform 6 is the major neuronal form. Isoform 8 isexpressed in spinal cord and brain. Isoform 9 is the major form inskeletal muscle cells; in the nervous system it is expressed inspinal cord and brain. Also detected in adult heart placenta lung liver kidney and pancreas. Isoform 10 is expressed innervous system: spinal cord motor neurons dorsal root ganglionneurons and brain. Predominant isoform expressed in sensory andmotor neurons. Not detected in adult heart placenta lung liver skeletal muscle kidney and pancreas. Not expressed in fetallung liver and kidney. Type IV isoforms are brain-specific.