CA-5f
Product Specifications
UNSPSC Description
CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion. CA-5f increases LC3B-II (a marker to monitor autophagy) and SQSTM1 protein, and also increases ROS production. Anti-tumor activity[1].
Target Antigen
Apoptosis; Atg8/LC3; Autophagy; p62
Type
Reference compound
Related Pathways
Apoptosis;Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CA-5f.html
Purity
99.14
Solubility
DMSO : 77.5 mg/mL (ultrasonic)
Smiles
O=C(/C(CN(C)C/1)=C/C2=CNC3=C2C=CC=C3)C1=C\C4=CC=C(OC)C(OC)=C4
Molecular Weight
388.46
References & Citations
[1]Zhang L, et al. Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer. Autophagy. 2019 Mar;15(3):391-406.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-112698/CA-5f-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-112698/CA-5f-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1370032-19-1
Available Sizes
Curated Selection
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