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Lurtotecan

Lurtotecan (GI147211; OSI-211), a semisynthetic Camptothecin analog, is a topoisomerase I inhibitor. Lurtotecan has anticancer effects[1].

Product Specifications

CAS Number

149882-10-0

Product Name Alternative

GI147211; OSI-211

UNSPSC

12352005

Hazard Statement

H301-H311-H331

Target

Topoisomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/lurtotecan.html

Purity

98.07

Solubility

DMSO : 4.33 mg/mL (ultrasonic)

Smiles

O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C(CN5CCN(C)CC5)C6=CC(OCCO7)=C7C=C6N=C4C3=C2)=O

Molecular Formula

C28H30N4O6

Molecular Weight

518.56

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501

References & Citations

[1]D L Emerson, et al. In vivo antitumor activity of two new seven-substituted water-soluble camptothecin analogues. Cancer Res. 1995 Feb 1;55 (3) :603-9.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Isoform

Topo I

Available Sizes

Frequently Asked Questions

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