PS48

PS48 is an activator of PDK1 with an AC50 of 8 μM.

Product Specifications

CAS Number

[1180676-32-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PDK-1

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/PS48.html

Purity

99.71

Solubility

H2O : < 0.1 mg/mL (ultrasonic)

Smiles

O=C(O)/C=C(C1=CC=CC=C1)/CCC2=CC=C(Cl)C=C2

Molecular Formula

C17H15ClO2

Molecular Weight

286.75

Precautions

H302, H315, H319, H335

References & Citations

[1]Hindie V, et al. Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nat Chem Biol. 2009 Oct;5 (10) :758-64.|[2]Han F, et al. Triptolide Suppresses Glomerular Mesangial Cell Proliferation in Diabetic Nephropathy Is Associated with Inhibition of PDK1/Akt/mTOR Pathway. Int J Biol Sci. 2017 Sep 21;13 (10) :1266-1275.