1,11b-Dihydro-11b-hydroxymedicarpin
1,11b-Dihydro-11b-hydroxymedicarpin (11b-Hydroxy-11b,1-dihydromedicarpin) is a pterocarpan from Ononis viscosa subsp. breviflora is a Medicarpin derivative[1]. Medicarpin, a natural pterocarpan, heals cortical bone defect by activation of Notch and Wnt canonical signaling pathways[2]. Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Medicarpin down-regulates pro-inflammatory cytokines like TNF-α, IL-6 and IL-17A, while up-regulates anti-inflammatory cytokine IL-10 in arthritis (CIA) model of mice[3].
Product Specifications
CAS Number
210537-04-5
Product Name Alternative
11b-Hydroxy-11b,1-dihydromedicarpin
UNSPSC
12352005
Target
Interleukin Related; Wnt
Type
Natural Products
Related Pathways
Immunology/Inflammation; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/1-11b-dihydro-11b-hydroxymedicarpin.html
Solubility
10 mM in DMSO
Smiles
O=C(CC1)C=C2[C@@]1(O)[C@@](OC3=CC(OC)=CC=C34)([H])[C@@]4([H])CO2
Molecular Formula
C16H16O5
Molecular Weight
288.30
References & Citations
Ononis viscosabreviflora
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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