Bomedemstat (ditosylate)
Bomedemstat (IMG-7289) ditosylate is an orally active and irreversible lysine-specific demethylase 1 (LSD1) inhibitor. Bomedemstat ditosylate can increase H3K4 and H3K9 methylation, and then alter gene expression. Bomedemstat ditosylate shows anti-cancer activities, inhibits cancer cell proliferation and induces apoptosis[1][2].
Product Specifications
CAS Number
1990504-72-7
Product Name Alternative
IMG-7289 (ditosylate)
UNSPSC
12352005
Target
Apoptosis; Histone Demethylase
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bomedemstat-ditosylate.html
Purity
99.14
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1CCN(CC1)C)[C@@H](NC(C2=CC=C(N3C=CN=N3)C=C2)=O)CCCN[C@H]4[C@@](C5=CC=C(C=C5)F)([H])C4.O=S(C6=CC=C(C)C=C6)(O)=O.O=S(C7=CC=C(C)C=C7)(O)=O
Molecular Formula
C42H50FN7O8S2
Molecular Weight
864.02
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
KDM1/LSD1
Citation 01
Nat Commun. 2025 Feb 1;16 (1) :1241.|Nature. 2025 Jun;642 (8067) :508-518.|Proc Natl Acad Sci U S A. 2025 May 20;122 (20) :e2425812122.
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