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(S) -Selisistat

(S) -Selisistat ((S) -EX-527) is a potent and selective SIRT1 inhibitor, with an IC50 of 98 nM.

Product Specifications

CAS Number

848193-68-0

Product Name Alternative

(S) -EX-527

UNSPSC

12352005

Hazard Statement

H302-H317

Target

Sirtuin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/EX-527-S-enantiomer.html

Purity

99.39

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C([C@@H]1C(NC2=C3C=C(Cl)C=C2)=C3CCC1)N

Molecular Formula

C13H13ClN2O

Molecular Weight

248.71

Precautions

P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P501

References & Citations

[1]Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15;48 (25) :8045-54.|[2]Solomon JM, et al. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol. 2006 Jan;26 (1) :28-38.|[3]Jia Y, et al. SIRT1 is a regulator in high glucose-induced inflammatory response in RAW264.7 cells. PLoS One. 2015 Mar 20;10 (3) :e0120849.|[4]Wang X, et al. Resveratrol attenuates microvascular inflammation in sepsis via SIRT-1-Induced modulation of adhesion molecules in ob/ob mice. Obesity (Silver Spring) . 2015 Jun;23 (6) :1209-17.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

SIRT1

Available Sizes

Frequently Asked Questions

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