(S) -Selisistat
(S) -Selisistat ((S) -EX-527) is a potent and selective SIRT1 inhibitor, with an IC50 of 98 nM.
Product Specifications
CAS Number
[848193-68-0]
Product Name Alternative
(S) -EX-527
UNSPSC
12352005
Hazard Statement
H302-H317
Target
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/EX-527-S-enantiomer.html
Purity
99.39
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C([C@@H]1C(NC2=C3C=C(Cl)C=C2)=C3CCC1)N
Molecular Formula
C13H13ClN2O
Molecular Weight
248.71
Precautions
P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P501
References & Citations
[1]Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15;48 (25) :8045-54.|[2]Solomon JM, et al. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol. 2006 Jan;26 (1) :28-38.|[3]Jia Y, et al. SIRT1 is a regulator in high glucose-induced inflammatory response in RAW264.7 cells. PLoS One. 2015 Mar 20;10 (3) :e0120849.|[4]Wang X, et al. Resveratrol attenuates microvascular inflammation in sepsis via SIRT-1-Induced modulation of adhesion molecules in ob/ob mice. Obesity (Silver Spring) . 2015 Jun;23 (6) :1209-17.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT1
Available Sizes
Curated Selection
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