R-HP210
R-HP210 acts on the NF-κB mediated tethered transrepression function (IC50=3.80 μM) . R-HP210 represses the LPS-induced transcription of a variety of proinflammatory genes such as IL-1β, IL-6 and COX-2. R-HP210 does not induce the transactivation functions of Glucocorticoids (GCs) [1].
Product Specifications
UNSPSC
12352005
Target
NF-κB
Type
Reference compound
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/r-hp210.html
Purity
98.21
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
C[C@H](C1=CC=CC=C1)NC(C2=CC=C(C=C2)CN3C(C4=C(NC3=S)C=CS4)=O)=O
Molecular Formula
C22H19N3O2S2
Molecular Weight
421.54
References & Citations
[1]Xueping Hu, et al. Discovery of novel non-steroidal selective glucocorticoid receptor modulators by structure- and IGN-based virtual screening, structural optimization, and biological evaluation. Eur J Med Chem. 2022 Jul 5;237:114382.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NF-κB
Available Sizes
Frequently Asked Questions
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