R-HP210

R-HP210 acts on the NF-κB mediated tethered transrepression function (IC50=3.80 μM) . R-HP210 represses the LPS-induced transcription of a variety of proinflammatory genes such as IL-1β, IL-6 and COX-2. R-HP210 does not induce the transactivation functions of Glucocorticoids (GCs) [1].

Product Specifications

UNSPSC

12352005

Target

NF-κB

Type

Reference compound

Related Pathways

NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/r-hp210.html

Purity

98.21

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

C[C@H](C1=CC=CC=C1)NC(C2=CC=C(C=C2)CN3C(C4=C(NC3=S)C=CS4)=O)=O

Molecular Formula

C22H19N3O2S2

Molecular Weight

421.54

References & Citations

[1]Xueping Hu, et al. Discovery of novel non-steroidal selective glucocorticoid receptor modulators by structure- and IGN-based virtual screening, structural optimization, and biological evaluation. Eur J Med Chem. 2022 Jul 5;237:114382.