Sodium Channel inhibitor 1

Sodium Channel inhibitor1, one of 3-Oxoisoindoline-1-carboxamides, is a novel and selective voltage-gated sodium channel for pain treatment. IC50 Value: 0.16 uM (Na v1.7, V hold-90mV) ; 0.41 uM (Na v1.7, V hold-90mV) [1] Target: Na v1.7 Sodium Channel inhibitor1 demonstrated concentration-dependent efficacy in preclinical behavioral pain models.

Product Specifications

CAS Number

[1198117-23-5]

UNSPSC

12352005

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sodium-channel-inhibitor-1.html

Purity

99.38

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1N(CCC2=NC=CC=C2)C(C3=C1C(F)=CC=C3)=O)NCC4=CC=C(OC(F)(F)F)C=C4

Molecular Formula

C24H19F4N3O3

Molecular Weight

473.42

References & Citations

[1]Macsari I, et al. 3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na (V) 1.7with efficacy in rat pain models. J Med Chem. 2012 Aug 9;55 (15) :6866-80.