A 410099.1, amine-Boc (hydrochloride)

A 410099.1, amine-Boc hydrochloride is a functionalized IAP ligand and can be used for the synthesis of PROTACs, such as PROTACs targeting BTK (PROTACs 4 and 5) [1].

Product Specifications

CAS Number

[2374122-37-7]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/a-410099-1-amine-boc-hydrochloride.html

Purity

99.71

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N(C[C@H]1N)[C@@H](C1)C(N[C@H]2C3=CC=CC=C3CCC2)=O)[C@H](C4CCCCC4)NC([C@H](C)N(C)C(OC(C)(C)C)=O)=O.Cl

Molecular Formula

C32H50ClN5O5

Molecular Weight

620.22

Precautions

H315, H319, H320

References & Citations

[1]Christopher P Tinworth, et al. PROTAC-Mediated Degradation of Bruton's Tyrosine Kinase Is Inhibited by Covalent Binding. ACS Chem Biol.2019 Mar 15;14 (3) :342-347