Guangxitoxin 1E

Guangxitoxin 1E is a potent and selective blocker of KV2.1 and KV2.2 channels. Guangxitoxin 1E inhibits KV2 with an IC50 of 1-3 nM. KV2 channels underlie delayed-rectifier potassium currents in various neurons[1][2].

Product Specifications

CAS Number

[1233152-82-3]

UNSPSC

12352209

Target

Potassium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/guangxitoxin-1e.html

Purity

95.0

Solubility

H2O : ≥ 1 mg/mL

Smiles

O=C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CSSC[C@@H](C(N1[C@@H](CCC1)C(N[C@@H](CCCCN)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@H]3C(C)C)=O)=O)=O)=O)NC4=O)C(NCC(NCC(N[C@@H](CC5=CC=CC=C5)C(N[C@@H](CC6=CNC7=CC=CC=C67)C(N[C@@H](CC8=CNC9=CC=CC=C89)C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CO)C(N%10[C@@H](CCC%10)C(N[C@@H](CCCCN)C(N[C@@H](CC(/C%11=C/C)=CNC%11=C)C(NCC(N[C@H]%12CC(C)C)=O)=O)=O)=O)=O)=O)NC3=O)C(NCC(N[C@@H](CO)C(NCC(N[C@@H](CCCCN)C(N%13[C@@H](CCC%13)C(N[C@@H](C)C(N[C@H]4CSSC[C@@H](C(N[C@@H](CC(N)=O)C(N[C@@H](CC%14=CC=CC=C%14)C(N%15[C@@H](CCC%15)C(N[C@@H](CCSC)C(N%16[C@@H](CCC%16)C(O)=O)=O)=O)=O)=O)=O)NC%12=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCC(O)=O)N

Molecular Formula

C178H248N44O45S7

Molecular Weight

3948.61

References & Citations

[1]Hönigsperger C, et al. Physiological roles of Kv2 channels in entorhinal cortex layer II stellate cells revealed by Guangxitoxin-1E. J Physiol. 2017 Feb 1;595 (3) :739-757.|[2]Herrington J, et al. Blockers of the delayed-rectifier potassium current in pancreatic beta-cells enhance glucose-dependent insulin secretion. Diabetes. 2006 Apr;55 (4) :1034-42.