Nevanimibe hydrochloride
Product Specifications
UNSPSC Description
Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe hydrochloride inhibits ACAT2 with an EC50 of 368 nM. Nevanimibe hydrochloride induces cell apoptosis and has the potential for adrenocortical cancer[1].
Target Antigen
Acyltransferase; Apoptosis
Type
Reference compound
Related Pathways
Apoptosis;Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Nevanimibe_hydrochloride.html
Purity
99.92
Solubility
DMSO : 41.67 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C(NCC1(C2=CC=C(N(C)C)C=C2)CCCC1)NC3=C(C(C)C)C=CC=C3C(C)C.[H]Cl
Molecular Weight
458.08
References & Citations
[1]LaPensee CR, et al. ATR-101, a Selective and Potent Inhibitor of Acyl-CoA Acyltransferase 1, Induces Apoptosis in H295R Adrenocortical Cells and in the Adrenal Cortex of Dogs. Endocrinology. 2016 May;157(5):1775-88.Mol Cell Endocrinol. 2024 Oct 13:112385.|Structure. 2021 Sep 11;S0969-2126(21)00259-8.|Cell Rep. 2022 Nov 29;41(9):111724.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-100399A/Nevanimibe-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100399A/Nevanimibe-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
133825-81-7
Available Sizes
Curated Selection
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