Latrepirdine (dihydrochloride)

Latrepirdine dihydrochloride is a neuroactive compound with antagonist activity at histaminergic, α-adrenergic, and serotonergic receptors. Latrepirdine stimulates amyloid precursor protein (APP) catabolism and amyloid-β (Aβ) secretion.

Product Specifications

CAS Number

[97657-92-6]

Product Name Alternative

Dimebolin dihydrochloride

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H361

Target

5-HT Receptor; Adrenergic Receptor; Amyloid-β; Autophagy; Histamine Receptor

Type

Reference compound

Related Pathways

Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Latrepirdine-dihydrochloride.html

Purity

99.65

Solubility

DMSO : 6.4 mg/mL (warming) |H2O : 100 mg/mL (ultrasonic)

Smiles

CN(C1)CCC2=C1C3=CC(C)=CC=C3N2CCC4=CN=C(C)C=C4.Cl.Cl

Molecular Formula

C21H27Cl2N3

Molecular Weight

392.37

Precautions

H302, H315, H319, H361

References & Citations

[1]Steele JW, et al. Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model. Mol Psychiatry. 2013 Aug;18 (8) :889-97.