(Rac) -Lys-SMCC-DM1

(Rac) -Lys-SMCC-DM1 ((Rac) -Lys-Nε-MCC-DM1) is the racemate of Lys-SMCC-DM1 (HY-101982) . Lys-SMCC-DM1 is a linker-payload component that has the potential to inhibit tubulin polymerization. Lys-SMCC-DM1 is the active metabolite of T-DM1[1].

Product Specifications

Product Name Alternative

(Rac) -Lys-Nε-MCC-DM1

UNSPSC

12352203

Target

Drug-Linker Conjugates for ADC

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/rac-lys-smcc-dm1.html

Purity

98.18

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@]1([C@@](CC(N(C(C=C2C=C3OC)=C3Cl)C)=O)([H])OC([C@H](C)N(C)C(CCSC(CC4=O)C(N4C[C@@H]5CC[C@@H](C(NCCCC[C@H](N)C(O)=O)=O)CC5)=O)=O)=O)[C@H]([C@@H]([C@](OC6=O)([H])C[C@]([C@](/C=C/C=C(C)/C2)([H])OC)(N6)O)C)O1

Molecular Formula

C53H75ClN6O15S

Molecular Weight

1103.71

References & Citations

[1]Ogitani Y, et al. Bystander killing effect of DS-8201a, a novel anti-human epidermal growth factor receptor 2 antibody-drug conjugate, in tumors with human epidermal growth factor receptor 2 heterogeneity. Cancer Sci. 2016 Jul;107 (7) :1039-46.