PARP-1-IN-3
PARP-1-IN-3, a benzamide derivative, is a potent PARP-1 inhibitor with IC50 values of 0.25 nM and 2.34 nM for PARP-1 and PARP-2, respectively. PARP-1-IN-3 induces apoptosis and arrest cell cycle at G2/M phase. PARP-1-IN-3 can be used in research of cancer[1].
Product Specifications
CAS Number
2976342-33-1
UNSPSC
12352005
Target
Apoptosis; Caspase; PARP
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/parp-1-in-3.html
Purity
99.30
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
NC(C1=CC=CC=C1OCC2=CC=CC(NC(C3=CC=C(C=C3)Br)=O)=C2)=O
Molecular Formula
C21H17BrN2O3
Molecular Weight
425.28
References & Citations
[1]Lu G, et, al. Discovery of novel benzamide derivatives bearing benzamidophenyl and phenylacetamidophenyl scaffolds as potential antitumor agents via targeting PARP-1. Eur J Med Chem. 2023 May 5;251:115243.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP1; PARP2
Available Sizes
Frequently Asked Questions
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