PF-05105679

PF-05105679, a chemical probe, is an orally active and selective TRPM8 antagonist with an IC50 of 103 nM. PF-05105679 has the potential for cold-related pain[1].

Product Specifications

CAS Number

[1398583-31-7]

UNSPSC

12352005

Hazard Statement

H302

Target

TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pf-05105679.html

Purity

99.88

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(O)C1=CC=CC(CN([C@@H](C2=CC=C(F)C=C2)C)C(C3=CC4=CC=CC=C4N=C3)=O)=C1

Molecular Formula

C26H21FN2O3

Molecular Weight

428.45

Precautions

H302

References & Citations

[1]Andrews MD, et al. Discovery of a Selective TRPM8 Antagonist with Clinical Efficacy in Cold-Related Pain. ACS Med Chem Lett. 2015 Jan 30;6 (4) :419-24.