GePhos1
GePhos1, a EGFR-targeting PhosTAC (phosphorylation targeting chimera), induces EGFR dephosphorylation. GePhos1 induces apoptosis[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; EGFR
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gephos1.html
Purity
98.88
Solubility
10 mM in DMSO
Smiles
COC1=C(OC)C=CC(CC[C@H](C2=CC(OCC(NCCC(N3CCN(CCCOC4=CC5=C(NC6=CC=C(F)C(Cl)=C6)N=CN=C5C=C4OC)CC3)=O)=O)=CC=C2)OC([C@@H]7CCCCN7C([C@@H](CC)C8=CC(OC)=C(OC)C(OC)=C8)=O)=O)=C1
Molecular Formula
C63H75ClFN7O13
Molecular Weight
1192.76
References & Citations
[1]Zhenyi Hu, et al. EGFR targeting PhosTACs as a dual inhibitory approach reveals differential downstream signaling. Sci Adv. 2024 Mar 29;10 (13) :eadj7251.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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