GePhos1

GePhos1, a EGFR-targeting PhosTAC (phosphorylation targeting chimera), induces EGFR dephosphorylation. GePhos1 induces apoptosis[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; EGFR

Type

Reference compound

Related Pathways

Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gephos1.html

Purity

98.88

Solubility

10 mM in DMSO

Smiles

COC1=C(OC)C=CC(CC[C@H](C2=CC(OCC(NCCC(N3CCN(CCCOC4=CC5=C(NC6=CC=C(F)C(Cl)=C6)N=CN=C5C=C4OC)CC3)=O)=O)=CC=C2)OC([C@@H]7CCCCN7C([C@@H](CC)C8=CC(OC)=C(OC)C(OC)=C8)=O)=O)=C1

Molecular Formula

C63H75ClFN7O13

Molecular Weight

1192.76

References & Citations

[1]Zhenyi Hu, et al. EGFR targeting PhosTACs as a dual inhibitory approach reveals differential downstream signaling. Sci Adv. 2024 Mar 29;10 (13) :eadj7251.