JB-95 (acetate)
Product Specifications
UNSPSC Description
JB-95 acetate, a β-hairpin macrocyclic peptide, exhibits potent antimicrobial activity against Escherichia coli. JB-95 acetate can selectively disrupt the outer membrane but not the inner membrane of E. coli[1].
Target Antigen
Bacterial
Type
Peptides
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/jb-95-acetate.html
Purity
98.39
Solubility
H2O : ≥ 50 mg/mL
Smiles
O=C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@@](C(N[C@@H](C(N[C@H](C(N[C@H]1CCCCN)=O)CC2=CNC3=CC=CC=C23)=O)CCCNC(N)=N)=O)([H])[C@@H](C)CC)=O)CCCNC(N)=N)=O)([H])[C@@H](C)CC)=O)CCCNC(N)=N)[C@@H](NC([C@@](CCC4)([H])N4C([C@](CCC5)([H])N5C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC1=O)CCCNC(N)=N)=O)CC(C)C)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)=O)=O)CC6=CNC7=CC=CC=C67.CC(O)=O.[x]
Molecular Weight
1971.41 (free base)
References & Citations
[1]Urfer M, et, al. A Peptidomimetic Antibiotic Targets Outer Membrane Proteins and Disrupts Selectively the Outer Membrane in Escherichia coli. J Biol Chem. 2016 Jan 22;291(4):1921-1932.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P5753A/JB-95-acetate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P5753A/JB-95-acetate-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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