MIPS-9922
MIPS-9922 is a potent and selective PI3Kβ inhibitor with an IC50 of 63 nM. MIPS-9922 inhibits PI3Kβ with >30-fold higher potency than PI3Kδ. MIPS-9922 blocks PI3K mediated activation of platelet glycoprotein αIIbβ3 activation and platelet adhesion in vitro. MIPS-9922 shows anti-platelet and anti-thrombotic activities[1].
Product Specifications
CAS Number
[1416956-33-6]
UNSPSC
12352005
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/mips-9922.html
Purity
99.2500
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1CCN(C2=NC(N3C4=CC=CC=C4N=C3C(F)F)=NC(N5CCOCC5)=N2)CC1)[C@@H](N)CC6=CC=CC=C6
Molecular Formula
C28H31F2N9O2
Molecular Weight
563.60
References & Citations
[1]Zhaohua Zheng, et al. Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922) . Eur J Med Chem. 2016 Oct 21:122:339-351.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kβ; PI3Kδ
Available Sizes
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