OG-L002

OG-L002 is a potent and highly selective LSD1 inhibitor with an IC50 of 0.02 μM. OG-L002 is a potent monoamine oxidases (MAO) inhibitor with IC50s of 1.38 μM and 0.72 μM for MAO-A and MAO-B, respectively. OG-L002 potently inhibits the expression of HSV IE genes[1].

Product Specifications

CAS Number

[1357302-64-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Histone Demethylase; HSV; Monoamine Oxidase

Type

Reference compound

Related Pathways

Anti-infection; Epigenetics; Neuronal Signaling

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/og-l002.html

Purity

99.55

Solubility

DMSO : ≥ 100 mg/mL

Smiles

OC1=CC(C2=CC=C([C@@H]3[C@@H](N)C3)C=C2)=CC=C1

Molecular Formula

C15H15NO

Molecular Weight

225.29

Precautions

H302, H315, H319, H335

References & Citations

[1]Liang Y, et al. A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency. mBio. 2013 Feb 5;4 (1) :e00558-12.