Diethyltoluamide

Diethyltoluamide (DEET) is the most common active ingredient in insect repellents. It is intended to provide protection against mosquitoes, ticks, fleas, chiggers, leeches, and many other biting insects. Diethyltoluamide is toxic to hepatocytes and can lead to many physiological, pharmacological, and behavioral abnormalities, particularly motor deficits and learning and memory dysfunction[1][2][3].

Product Specifications

CAS Number

[134-62-3]

Product Name Alternative

DEET; N, N-Diethyl-m-toluamide

UNSPSC

12352005

Hazard Statement

H302, H313, H315, H319, H335, H402, H412

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/DEET.html

Purity

99.69

Solubility

DMSO : ≥ 100 mg/mL|H2O : 2 mg/mL (ultrasonic)

Smiles

O=C(N(CC)CC)C1=CC=CC(C)=C1

Molecular Formula

C12H17NO

Molecular Weight

191.27

Precautions

H302, H313, H315, H319, H335, H402, H412

References & Citations

[1]Lu W, et al. DEET as a feeding deterrent. PLoS One. 2017 Dec 14;12 (12) :e0189243.|[2]Das PC, et al. Enzyme induction and cytotoxicity in human hepatocytes by chlorpyrifos and N, N-diethyl-m-toluamide (DEET) . Drug Metabol Drug Interact. 2008;23 (3-4) :237-60.|[3]Abdel-Rahman A, et al. Subchronic dermal application of N, N-diethyl m-toluamide (DEET) and permethrin to adult rats, alone or in combination, causes diffuse neuronal cell death and cytoskeletal abnormalities in the cerebral cortex and the hippocampus, and Purkinje neuron loss in the cerebellum. Exp Neurol. 2001 Nov;172 (1) :153-71.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

Mite

Available Sizes

Curated Selection

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