(R) -IBR2

(R) -IBR2 is the isomer of IBR2 (HY-103710) . IBR2 is a potent and specific RAD51 inhibitor and inhibits RAD51-mediated DNA double-strand break repair. IBR2 disrupts RAD51 multimerization, accelerates proteasome-mediated RAD51 protein degradation, inhibits cancer cell growth and induces apoptosis[1].

Product Specifications

CAS Number

[952739-54-7]

UNSPSC

12352005

Target

RAD51

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/r-ibr2.html

Smiles

O=S(N1[C@@H](C2=CNC3=C2C=CC=C3)C4=C(C=CC=C4)C=C1)(CC5=CC=CC=C5)=O

Molecular Formula

C24H20N2O2S

Molecular Weight

400.49

References & Citations

[1]Zhu J, et al. A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia. EMBO Mol Med. 2013 Mar;5 (3) :353-65.