MCPA

MCPA is an orally active phenoxyacetic acid herbicide. MCPA interferes with membrane integrity, energy metabolism (decreases ATP levels), and redox balance in plant cells. MCPA increases hepatic cytochrome P-450 levels and increases aniline hydroxylase and 7-ethoxycoumarin O-deethylase activities. MCPA can be used to control broadleaf weeds[1][2][3][4][5].

Product Specifications

CAS Number

[94-74-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H318, H410

Target

Cytochrome P450; Herbicide

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/mcpa.html

Purity

98.95

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(O)COC1=CC=C(Cl)C=C1C

Molecular Formula

C9H9ClO3

Molecular Weight

200.62

Precautions

H302, H315, H318, H410

References & Citations

[1]Kimura O, et al. Uptake of 4-chloro-2-methylphenoxyacetic acid (MCPA) from the apical membrane of Caco-2 cells by the monocarboxylic acid transporter. Toxicol Appl Pharmacol. 2008 Mar 15;227 (3) :325-30.|[2]Peixoto F P, et al. Toxicity of MCPA on non-green potato tuber calli. Acta Physiologiae Plantarum, 2009, 31 (1) : 103-109. |[3]Gao Y F, et al. The influence of chlorophenoxy herbicides MCPA on creeping bentgrass physiological index. Advanced Materials Research, 2012, 356: 2763-2766. |[4]Inomata N, et al. Effects of MCPA and other phenoxyacid compounds on hepatic xenobiotic metabolism in rats. Tohoku J Exp Med. 1991 Nov;165 (3) :171-82.|[5]van Ravenzwaay B, et al. Absorption, distribution, metabolism and excretion of 4-chloro-2-methylphenoxyacetic acid (MCPA) in rats. Food Chem Toxicol. 2004 Jan;42 (1) :115-25.