SJG-136
SJG-136 is a DNA cross-linking agent, with an XL50 of 45 nM for pBR322 DNA. SJG-136 has potent antitumor activity.
Product Specifications
CAS Number
232931-57-6
Product Name Alternative
NSC-694501
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Payload; DNA Alkylator/Crosslinker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SJG-136.html
Purity
99.47
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
O=C1N2[C@@H](CC(C2)=C)C=NC3=CC(OCCCOC4=C(OC)C=C(C(N(CC(C5)=C)[C@@H]5C=N6)=O)C6=C4)=C(OC)C=C31
Molecular Formula
C31H32N4O6
Molecular Weight
556.61
Precautions
H302, H315, H319, H335
References & Citations
[1]Gregson SJ, et al. Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity. J Med Chem. 2001 Mar 1;44 (5) :737-48.|[2]Mellinas-Gomez M, et al. Activity of the DNA minor groove cross-linking agent SG2000 (SJG-136) against canine tumours. BMC Vet Res. 2015 Aug 19;11:215.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
Phase 2
Isoform
Pyrrolobenzodiazepines
Available Sizes
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