SJG-136

SJG-136 is a DNA cross-linking agent, with an XL50 of 45 nM for pBR322 DNA. SJG-136 has potent antitumor activity.

Product Specifications

CAS Number

[232931-57-6]

Product Name Alternative

NSC-694501

UNSPSC

12352203

Hazard Statement

H302, H315, H319, H335

Target

ADC Payload; DNA Alkylator/Crosslinker

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/SJG-136.html

Purity

99.47

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

O=C1N2[C@@H](CC(C2)=C)C=NC3=CC(OCCCOC4=C(OC)C=C(C(N(CC(C5)=C)[C@@H]5C=N6)=O)C6=C4)=C(OC)C=C31

Molecular Formula

C31H32N4O6

Molecular Weight

556.61

Precautions

H302, H315, H319, H335

References & Citations

[1]Gregson SJ, et al. Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity. J Med Chem. 2001 Mar 1;44 (5) :737-48.|[2]Mellinas-Gomez M, et al. Activity of the DNA minor groove cross-linking agent SG2000 (SJG-136) against canine tumours. BMC Vet Res. 2015 Aug 19;11:215.