P2X4 antagonist-1
P2X4 antagonist-1 (Compound 24) is an antagonist for P2X4 with IC50 of 15 nM[1].
Product Specifications
CAS Number
2055601-42-6
UNSPSC
12352005
Target
P2X Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/p2x4-antagonist-1.html
Purity
99.89
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC1=CC=CC(OC2=C(S(=O)(N)=O)C=C(NC(CC3=C(Cl)C=CC=C3Cl)=O)C=C2)=C1
Molecular Formula
C20H15Cl3N2O4S
Molecular Weight
485.77
References & Citations
[1]Werner S, et al., Discovery and characterization of the potent and selective P2X4 inhibitor N-[4- (3-Chlorophenoxy) -3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and structure-guided amelioration of its CYP3A4 induction profile[J]. Journal of Medicinal Chemistry, 2019, 62 (24) : 11194-11217.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2X4 Receptor
Available Sizes
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