P2X4 antagonist-1

P2X4 antagonist-1 (Compound 24) is an antagonist for P2X4 with IC50 of 15 nM[1].

Product Specifications

CAS Number

[2055601-42-6]

UNSPSC

12352005

Target

P2X Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/p2x4-antagonist-1.html

Purity

99.89

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

ClC1=CC=CC(OC2=C(S(=O)(N)=O)C=C(NC(CC3=C(Cl)C=CC=C3Cl)=O)C=C2)=C1

Molecular Formula

C20H15Cl3N2O4S

Molecular Weight

485.77

References & Citations

[1]Werner S, et al., Discovery and characterization of the potent and selective P2X4 inhibitor N-[4- (3-Chlorophenoxy) -3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and structure-guided amelioration of its CYP3A4 induction profile[J]. Journal of Medicinal Chemistry, 2019, 62 (24) : 11194-11217.