Mulberrofuran G

Mulberrofuran G is a NOX inhibitor (IC50: 6.9 μM) and tyrosinase inhibitor. Mulberrofuran G exhibits anti-inflammatory, antioxidant, antiviral, antitumor, and neuroprotective effects. Mulberrofuran G can be used in the research of tumors, nervous system diseases, and other conditions[1][2][3][4][5].

Product Specifications

CAS Number

[87085-00-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Caspase; HBV; JAK; NADPH Oxidase; PARP; Reactive Oxygen Species (ROS) ; SARS-CoV; STAT; Tyrosinase

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mulberrofuran-g.html

Purity

97.86

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC1=C(C=CC(O)=C1)[C@]23[C@]4([H])[C@](C=C(C)C[C@@]4([H])C5=C(C=C(O)C=C5)O3)([H])C6=C(O)C=C(C7=CC8=C(C=C(O)C=C8)O7)C=C6O2

Molecular Formula

C34H26O8

Molecular Weight

562.57

Precautions

H302, H315, H319, H335

References & Citations

[1]Hong S, et al. Mulberrofuran G Protects Ischemic Injury-induced Cell Death via Inhibition of NOX4-mediated ROS Generation and ER Stress. Phytother Res. 2017;31 (2) :321-329.|[2]Geng CA, et al. Mulberrofuran G and isomulberrofuran G from Morus alba L.: anti-hepatitis B virus activity and mass spectrometric fragmentation. J Agric Food Chem. 2012;60 (33) :8197-8202.|[3]HaiYuanBo G, et al. Mulberrofuran G inhibits proliferation and migration by inactivating JAK2/STAT3 signaling in lung cancer cells. Bangladesh Journal of Pharmacology, 2021, 16 (4) : 134-140.|[4]Kim YS, et al. Mulberrofuran G, a Mulberry Component, Prevents SARS-CoV-2 Infection by Blocking the Interaction between SARS-CoV-2 Spike Protein S1 Receptor-Binding Domain and Human Angiotensin-Converting Enzyme 2 Receptor. Nutrients. 2022 Oct 7;14 (19) :4170.|[5]Koirala P, et al. Structure⁻Activity Relationship of the Tyrosinase Inhibitors Kuwanon G, Mulberrofuran G, and Albanol B from Morus Species: A Kinetics and Molecular Docking Study. Molecules. 2018 Jun 11;23 (6) :1413.