Ac-YVAD-AFC

Ac-YVAD-AFC is the the fluorometric peptide substrate of caspase-1, with λ excitation of 400 nm and λ emission of 505 nm[1][2].

Product Specifications

CAS Number

[219137-85-6]

UNSPSC

12171500

Target

Fluorescent Dye

Type

Dye Reagents

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ac-yvad-afc.html

Purity

99.56

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC(F)(C(C(C(O1)=C2)=CC=C2NC([C@H](CC(O)=O)NC([C@H](C)NC([C@H](C(C)C)NC([C@@H](NC(C)=O)CC(C=C3)=CC=C3O)=O)=O)=O)=O)=CC1=O)F

Molecular Formula

C33H36F3N5O10

Molecular Weight

719.66

References & Citations

[1]Furuoka M, et al. TNF-α Induces Caspase-1 Activation Independently of Simultaneously Induced NLRP3 in 3T3-L1 Cells. J Cell Physiol. 2016 Dec;231 (12) :2761-7.|[2]Guo RF, et al. Protective effects of anti-C5a in sepsis-induced thymocyte apoptosis. J Clin Invest. 2000 Nov;106 (10) :1271-80.