Ac-YVAD-AFC
Ac-YVAD-AFC is the the fluorometric peptide substrate of caspase-1, with λ excitation of 400 nm and λ emission of 505 nm[1][2].
Product Specifications
CAS Number
[219137-85-6]
UNSPSC
12171500
Target
Fluorescent Dye
Type
Dye Reagents
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ac-yvad-afc.html
Purity
99.56
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(F)(C(C(C(O1)=C2)=CC=C2NC([C@H](CC(O)=O)NC([C@H](C)NC([C@H](C(C)C)NC([C@@H](NC(C)=O)CC(C=C3)=CC=C3O)=O)=O)=O)=O)=CC1=O)F
Molecular Formula
C33H36F3N5O10
Molecular Weight
719.66
References & Citations
[1]Furuoka M, et al. TNF-α Induces Caspase-1 Activation Independently of Simultaneously Induced NLRP3 in 3T3-L1 Cells. J Cell Physiol. 2016 Dec;231 (12) :2761-7.|[2]Guo RF, et al. Protective effects of anti-C5a in sepsis-induced thymocyte apoptosis. J Clin Invest. 2000 Nov;106 (10) :1271-80.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Dye Reagents
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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