Oridonin (Standard)

Oridonin (Standard) is the analytical standard of Oridonin. This product is intended for research and analytical applications. Oridonin (NSC-250682), a diterpenoid isolated from Rabdosia rubescens, acts as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2; Oridonin possesses anti-tumor, anti-bacterial and anti-inflammatory effects.

Product Specifications

CAS Number

[28957-04-2]

Product Name Alternative

NSC-250682 (Standard) ; Isodonol (Standard)

UNSPSC

12352005

Target

Akt; Bacterial; Reference Standards

Type

Reference Standards

Related Pathways

Anti-infection; Others; PI3K/Akt/mTOR

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/oridonin-standard.html

Smiles

O[C@@H]1[C@]2(CO3)[C@@]([C@H](O)[C@]3(O)[C@]45[C@@]2([H])CC[C@](C(C5=O)=C)([H])[C@@]4([H])O)([H])C(C)(C)CC1

Molecular Formula

C20H28O6

Molecular Weight

364.43

References & Citations

[1]Song M, et al. Targeting AKT with oridonin inhibits growth of esophageal squamous cell carcinoma in vitro and patient derived xenografts in vivo. Mol Cancer Ther. 2018 Apr 25. pii: molcanther.0823.2017.|[2]Sun B, et al. Oridonin inhibits aberrant AKT activation in breast cancer. Oncotarget. 2018 Feb 1;9 (35) :23878-23889.