UNC-2170 (maleate)
UNC-2170 maleate is the maleate salt form of UNC-2170. UNC-2170 maleate is a selective inhibitor for the methyl-lysine binding protein 53BP1, with IC50 of 29 µM and Kd of 22 µM. UNC-2170 maleate shows at least 17-fold selectivity for 53BP1 as compared to nine other methyl-lysine (Kme) reader proteins. 53BP1 is a Kme binding protein that plays a central role in DNA Damage Repair (DDR) pathways and is recruited to sites of double-strand breaks (DSB).
Product Specifications
CAS Number
2173992-60-2
UNSPSC
12352005
Hazard Statement
H302-H312-H332
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/unc-2170-maleate.html
Smiles
O=C(NCCCNC(C)(C)C)C1=CC=CC(Br)=C1.O=C(O)/C=C/C(O)=O
Molecular Formula
C18H25BrN2O5
Molecular Weight
429.31
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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