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BC-​1258

BC-1258, an F-box/LRR-repeat protein 2 (FBXL2) activator, can stabilize and upregulate FBXL2 levels. BC-1258 induces apoptosis of tumorigenic cells, and profoundly inhibits tumor formation in mice[1].

Product Specifications

CAS Number

1507370-40-2

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bc-1258.html

Purity

99.26

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

C1(CNCCNCC2=CC=C(C3=NC=CS3)C=C2)=CC=C(C4=NC=CS4)C=C1

Molecular Formula

C22H22N4S2

Molecular Weight

406.57

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Chen BB, et, al. Skp-cullin-F box E3 ligase component FBXL2 ubiquitinates Aurora B to inhibit tumorigenesis. Cell Death Dis. 2013 Aug 8;4 (8) :e759.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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