BC-1258
BC-1258, an F-box/LRR-repeat protein 2 (FBXL2) activator, can stabilize and upregulate FBXL2 levels. BC-1258 induces apoptosis of tumorigenic cells, and profoundly inhibits tumor formation in mice[1].
Product Specifications
CAS Number
[1507370-40-2]
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bc-1258.html
Purity
99.26
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
C1(CNCCNCC2=CC=C(C3=NC=CS3)C=C2)=CC=C(C4=NC=CS4)C=C1
Molecular Formula
C22H22N4S2
Molecular Weight
406.57
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Chen BB, et, al. Skp-cullin-F box E3 ligase component FBXL2 ubiquitinates Aurora B to inhibit tumorigenesis. Cell Death Dis. 2013 Aug 8;4 (8) :e759.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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