ISR-IN-2
ISR-IN-2 (Compound 47) is an inhibitor of the integrated stress response (EC50: 0.8 nM) [1].
Product Specifications
CAS Number
[1628478-12-5]
UNSPSC
12352005
Hazard Statement
H302
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/isr-in-2.html
Purity
98.21
Solubility
DMSO : 2.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
ClC(C=C1OCC(N[C@H](CC2)CC[C@@H]2NC(COC3=CC(Cl)=C(C=C3)Cl)=O)=O)=C(C=C1)Cl
Molecular Formula
C22H22Cl4N2O4
Molecular Weight
520.23
Precautions
P264-P270-P330-P501
References & Citations
[1]Hearn BR, et al. Structure-Activity Studies of Bis-O-Arylglycolamides: Inhibitors of the Integrated Stress Response. ChemMedChem. 2016 Apr 19;11 (8) :870-80.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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