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Acetylene-linker-Val-Cit-PABC-MMAE

Acetylene-linker-Val-Cit-PABC-MMAE (LCB14-0602) consists the ADCs linker (Acetylene-linker-Val-Cit-PABC) and potent tubulin inhibitor (MMAE) . Acetylene-linker-Val-Cit-PABC-MMAE (LCB14-0602) is a agent-linker conjugate for ADC. Acetylene-linker-Val-Cit-PABC-MMAE is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[1411977-95-1]

Product Name Alternative

LCB14-0602

UNSPSC

12352203

Target

Drug-Linker Conjugates for ADC

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Acetylene-linker-Val-Cit-PABC-MMAE.html

Purity

95.21

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(COCCOCCOCC#C)=O)=O)NC1=CC=C(COC(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N([C@H]([C@@H](CC(N2[C@H]([C@H](OC)[C@H](C(N[C@@H]([C@@H](O)C3=CC=CC=C3)C)=O)C)CCC2)=O)OC)[C@@H](C)CC)C)=O)=O)=O)C=C1

Molecular Formula

C67H106N10O16

Molecular Weight

1307.62

References & Citations

[1]PROTEIN-ACTIVE AGENT CONJUGATES AND METHOD FOR PREPARING THE SAME. WIPO Patent Application WO/2012/153193.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, stored under nitrogen)

Scientific Category

ADC Related

Clinical Information

No Development Reported

Isoform

Auristatin

Available Sizes

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