VL285 Phenol

VL285 Phenol is a phenol-based VL285 analog. VL285 is an E3 ubiquitin ligase VHL ligand and can be used in the synthesis of HaloPROTAC3, degrading HaloTag7 fusion protein (IC50=0.34 μM) .

Product Specifications

CAS Number

[1448188-69-9]

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Ligands for E3 Ligase

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vl285-phenol.html

Purity

98.56

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(N=CS1)=C1C2=CC(O)=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](N4CC(C=CC=C5)=C5C4=O)C(C)C)=O)=O)C=C2

Molecular Formula

C29H32N4O5S

Molecular Weight

548.65

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501

References & Citations

[1]Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins. ACS Chem Biol. 2015 Aug 21;10 (8) :1831-7.