G-Protein antagonist peptide (TFA)

G-Protein antagonist peptide TFA is a truncated substance P-related peptide, competes with receptor for G protein binding. G-Protein antagonist peptide TFA inhibits the activation of Gi or Go by M2 muscarinic cholinergic receptor (M2 mAChR) or of Gs by beta-adrenergic receptor in the reconstituted phospholipid vesicles, assayed by receptor-promoted GTP hydrolysis[1].

Product Specifications

UNSPSC

12352209

Target

Adrenergic Receptor; mAChR

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/g-protein-antagonist-peptide-tfa.html

Purity

97.07

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CSCC[C@@H](C(N)=O)NC([C@@H](CC1=CNC2=C1C=CC=C2)NC([C@@H](CC3=CNC4=C3C=CC=C4)NC([C@H](CC5=CC=CC=C5)NC([C@@H](CC6=CNC7=C6C=CC=C7)NC([C@H](CCC(N)=O)NC([C@H](CC8)NC8=O)=O)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F

Molecular Formula

C59H65F3N12O11S

Molecular Weight

1207.28

References & Citations

[1]Mukai H, et al. G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding. J Biol Chem. 1992;267 (23) :16237-16243.