(R) -ADX-47273

(R) -ADX-47273 is a potent mGluR5 positive allosteric modulator, with an EC50 of 168 nM for potentiation .

Product Specifications

CAS Number

[851881-59-9]

UNSPSC

12352005

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/_R_-ADX-47273.html

Concentration

10mM

Purity

99.00

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N1C[C@H](C2=NC(C3=CC=C(C=C3)F)=NO2)CCC1)C4=CC=C(C=C4)F

Molecular Formula

C20H17F2N3O2

Molecular Weight

369.36

References & Citations

[1]Engers DW, et al. Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273. ChemMedChem. 2009 Apr;4 (4) :505-11.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MGluR5

Available Sizes

Curated Selection

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