DMeOB

DMeOB (3,3'-Dimethoxybenzaldazine) is a mGluR5 receptor negative allosteric modulator with an IC50 of 3 μM. DMeOB displays reversible non-competitive inhibition of mGlu5-mediated responses[1].

Product Specifications

CAS Number

[40252-74-2]

Product Name Alternative

3,3'-Dimethoxybenzaldazine

UNSPSC

12352005

Hazard Statement

H318, H410

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dmeob.html

Purity

98.55

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=CC(/C=N/N=C/C2=CC=CC(OC)=C2)=CC=C1

Molecular Formula

C16H16N2O2

Molecular Weight

268.31

Precautions

H318, H410

References & Citations

[1]O'Brien JA, et al. A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. Mol Pharmacol. 2003 Sep;64 (3) :731-40.