DMeOB
DMeOB (3,3'-Dimethoxybenzaldazine) is a mGluR5 receptor negative allosteric modulator with an IC50 of 3 μM. DMeOB displays reversible non-competitive inhibition of mGlu5-mediated responses[1].
Product Specifications
CAS Number
[40252-74-2]
Product Name Alternative
3,3'-Dimethoxybenzaldazine
UNSPSC
12352005
Hazard Statement
H318, H410
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dmeob.html
Purity
98.55
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=CC(/C=N/N=C/C2=CC=CC(OC)=C2)=CC=C1
Molecular Formula
C16H16N2O2
Molecular Weight
268.31
Precautions
H318, H410
References & Citations
[1]O'Brien JA, et al. A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. Mol Pharmacol. 2003 Sep;64 (3) :731-40.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR5
Available Sizes
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