Ergothioneine

Ergothioneine is an imidazole-2-thione derivative with orally active histidine betaine. Ergothioneine is a specific inhibitor of p38-MAPK and Akt, which plays a protective role in cell apoptosis induced by stress. Ergothioneine has antioxidant activity[1][2].

Product Specifications

CAS Number

[497-30-3]

Product Name Alternative

L- (+) -Ergothioneine

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Akt; Endogenous Metabolite; Keap1-Nrf2; NF-κB; p38 MAPK

Type

Natural Products

Related Pathways

MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ergothioneine.html

Purity

99.98

Solubility

H2O : 125 mg/mL (ultrasonic)

Smiles

S=C1NC(C[C@@H](C([O-])=O)[N+](C)(C)C)=CN1

Molecular Formula

C9H15N3O2S

Molecular Weight

229.31

Precautions

H302, H315, H319, H335

References & Citations

[1]Colognato R, et al. Modulation of hydrogen peroxide-induced DNA damage, MAPKs activation and cell death in PC12 by ergothioneine. Clin Nutr. 2006 Feb;25 (1) :135-45.|[2]Salama SA, et al. Ergothioneine mitigates cisplatin-evoked nephrotoxicity via targeting Nrf2, NF-κB, and apoptotic signaling and inhibiting γ-glutamyl transpeptidase. Life Sci. 2021 Aug 1;278:119572.