Sotrastaurin
Sotrastaurin (AEB071) is a potent and orally-active pan-PKC inhibitor, with Kis of 0.22 nM, 0.64 nM, 0.95 nM, 1.8 nM, 2.1 nM and 3.2 nM for PKCθ, PKCβ, PKCα, PKCη, PKCδ and PKCε, respectively[1].
Product Specifications
CAS Number
425637-18-9
Product Name Alternative
AEB071
UNSPSC
12352005
Hazard Statement
H301, H311, H331, H341
Target
MARCKS; PKC
Type
Reference compound
Related Pathways
Cytoskeleton; Epigenetics; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/Sotrastaurin.html
Purity
99.79
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C(C(C1=C2C=CC=CC2=NC(N3CCN(C)CC3)=N1)=C4C5=CNC6=C5C=CC=C6)NC4=O
Molecular Formula
C25H22N6O2
Molecular Weight
438.48
Precautions
H301, H311, H331, H341
References & Citations
[1]Evenou JP, et al. The potent protein kinase C-selective inhibitor AEB071 (sotrastaurin) represents a new class of immunosuppressive agents affecting early T-cell activation. J Pharmacol Exp Ther. 2009 Sep;330 (3) :792-801.|[2]Musi E, et al. The phosphoinositide 3-kinase α selective inhibitor BYL719 enhances the effect of the protein kinase C inhibitor AEB071 in GNAQ/GNA11-mutant uveal melanoma cells. Mol Cancer Ther. 2014 May;13 (5) :1044-53|[3]Kamo N, et al. Sotrastaurin, a protein kinase C inhibitor, ameliorates ischemia and reperfusion injury in rat orthotopic liver transplantation. Am J Transplant. 2011 Nov;11 (11) :2499-507.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
PKCα; PKCβ; PKCδ; PKCε; PKCη; PKCθ
Available Sizes
Frequently Asked Questions
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