Orotidine 5′-monophosphate (trisodium)
Orotidine 5'-monophosphate trisodium is a pyrimidine nucleotide. Orotidine 5'-monophosphate trisodium is synthesized via the de novo synthesis pathway for DNA synthesis in a large number of microorganisms including M. tuberculosis, S. cerevisiae, S. typhimurium and P. falciparum to name a few. The synthesis of orotidine 5'-monophosphate trisodium uses phosphoribosyl pyrophosphate (PRPP) and orotic acid (OA) as the substrates catalyzed by orotate phosphoribosyltransferase (OPRT) [1].
Product Specifications
CAS Number
[68244-58-6]
Product Name Alternative
Orotidine monophosphate (trisodium) ; Orotidylic acid (trisodium)
UNSPSC
12352005
Target
DNA/RNA Synthesis; Endogenous Metabolite
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/orotidine-5-monophosphate-trisodium.html
Purity
99.86
Solubility
H2O : 50 mg/mL (ultrasonic; warming)
Smiles
O=C(C(N([C@H]1[C@@H]([C@@H]([C@@H](COP(O[Na])(O[Na])=O)O1)O)O)C2=O)=CC(N2)=O)O[Na]
Molecular Formula
C10H10N2Na3O11P
Molecular Weight
434.14
References & Citations
[1]Subrahmanyeswara Rao NN, et al. QM/MM reveals the sequence of substrate binding during OPRT action. Comput Biol Chem. 2018 Jun;74:31-38.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite
Available Sizes
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