A2AR/A2BR antagonist 1
A2AR/A2BR antagonist 1 (compound 7ai) has a dual antagonistic effect on A2AR/A2BR, with the IC50 values of 11.2 nM and 6.4 nM for A2AR and A2BR, respectively. A2AR/A2BR antagonist 1 promotes T cell-mediated cancer cell death[1].
Product Specifications
UNSPSC
12352005
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/a2ar-a2br-antagonist-1-1.html
Solubility
10 mM in DMSO
Smiles
NC1=NC(C2=CN(N=N2)CC3=CNC4=C3C=C(C=C4)C#N)=CC(C5=CC=CC(C#N)=C5C)=N1
Molecular Formula
C24H17N9
Molecular Weight
431.45
References & Citations
[1]Wang H, et al. Subtle Structural Changes across the Boundary between A2AR/A2BR Dual Antagonism and A2BR Antagonism: A Novel Class of 2-Aminopyrimidine-Based Derivatives. J Med Chem. 2024 Mar 28;67 (6) :5075-5092.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Adenosine A2A receptor (A2AR) ; Adenosine A2B receptor (A2BR)
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